Hydrochloric Acid → HCID 86681662, compound

Participants

Reaction Steps

To a solution of methyl 2-(5-methoxy-6-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (0.200 g, 0.584 mmol) in dioxane (10 ml), aqueous 37% HCl (3.5 ml) was added, and the mixture was stirred at room temperature overnight. Additional aqueous 37% HCl (4 ml) was added over 30 hours with stirring the reaction at room temperature. The volatiles were removed under vacuum affording 2-(5-methoxy-6-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetic acid (0.183 g, 0.557 mmol, 95% yield). MS/ESI+ 328.9 [MH]+. This product was used without purification.

Provenance & Evidence