Methanesulfonyl chloride → HCID 86681667, compound

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Reaction Steps

To a solution of benzyl 2-(5-aminoindolin-1-yl)acetate (0.610 g, 2.161 mmol) in pyridine (15 ml), methanesulfonyl chloride (0.251 ml, 3.24 mmol) was added at 0° C. The mixture was allowed to warm to room temperature and stirred for 1 hour. The solvent was removed under vacuum and the residue was partitioned between DCM and water; the organic phase was washed with brine, dried over sodium sulfate and evaporated to dryness. The crude was purified by flash chromatography on silica gel column (petroleum ether:ethyl acetate=70:30 to 60:40) affording benzyl 2-(5-(methylsulfonamido)indolin-1-yl)acetate (0.565 g, 1.568 mmol, 73% yield). MS/ESI+ 361.0 [MH]+.

Provenance & Evidence