Methanesulfonyl chloride → HCID 86681669, compound

Participants

Reaction Steps

A solution of methyl 2-(6-amino-2-oxobenzo[d]oxazol-3(2H)-yl)acetate (0.497 g, 2.237 mmol) in pyridine (15 ml) was cooled to 0° C., and methanesulfonyl chloride (0.209 ml, 2.68 mmol) was added. The mixture was warmed to room temperature and stirred for 1 hour. The solvent was removed and the residue was portioned between ethyl acetate and 1N HCl. The organic phase was washed with brine and dried over sodium sulfate; the solvent was removed and the crude was purified by trituration with diethyl ether affording methyl 2-(6-(methylsulfonamido)-2-oxobenzo[d]oxazol-3(2H)-yl)acetate (0.523 g, 1.742 mmol, 78% yield). MS/ESI+ 300.9 [MH]+.

Provenance & Evidence