4,5-Dimethoxyphthalic acid → 5,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dione

Participants

Reaction Conditions

Reaction Steps

A suspension of 4,5-dimethoxyphthalic acid (600 mg, 2.65 mmol) in acetic anhydride (5 ml) was heated to 120° C. for 1 hour. The solvent was then removed under vacuum to afford 5,6-dimethoxyisobenzofuran-1,3-dione as a yellow solid (552 mg, 2.65 mmol, quantitative yield). MS/ESI+ 208.9 [MH]+. This compound was used as such in the next step.

Provenance & Evidence