反应详情

A mixture of tert-butyl 2-(4-nitro-1,3-dioxoisoindolin-2-yl)acetate (1.44 g, 4.70 mmol) and 10% w/w Pd/C (a catalytic amount) in MeOH (150 ml) was hydrogenated in a Parr apparatus at 25 psi for 3 hours. The catalyst was filtered off and the filtrate was evaporated; the residue was purified by a quick flash chromatography on silica gel (Hexane/EtOAc 1/1) to obtain tert-butyl 2-(4-amino-1,3-dioxoisoindolin-2-yl)acetate (712 mg, 2.58 mmol, 54.8% yield, MS/ESI+ 299.0 [MNa]+).

1. filtrationThe catalyst was filtered off
2. customthe filtrate was evaporated
3. customthe residue was purified by a quick flash chromatography on silica gel (Hexane/EtOAc 1/1)