Trifluoroacetic acid → 2-(4-(Methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetic acid

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Reaction Steps

A mixture of tert-butyl 2-(4-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (85 mg, 0.240 mmol) and TFA (370 μl, 4.80 mmol) in 5 ml of DCM was stirred at room temperature overnight. The mixture was evaporated to obtain 2-(4-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetic acid (72 mg, 0.240 mmol, 100% yield, MS/ESI+ 298.9 [MH]+) and used as such in the following reaction without further purification.

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