Hydrochloric Acid → HCID 86681692, compound

Participants

Reaction Steps

To a solution of methyl 2-(5-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (obtained as described in Example 30, Step 3, theoretical amount 1.622 mmol) in dioxane (10 ml), a 36% solution of HCl in water (10 ml) was added, and the mixture was stirred for 3 hours at room temperature. The volatiles were evaporated and the resulting crude was purified by flash chromatography on silica gel (eluent: DCM/MeOH 95:5). The title compound was obtained as a pale yellow solid (230 mg, 0.772 mmol, 47.6% yield over 2 steps, MS/ESI+ 299.1 [MH]+).

Provenance & Evidence