HCID 8820864, compound → HCID 86681697, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-(5-nitro-1,3-dioxoisoindolin-2-yl)acetate (15.7 g, 51.3 mmol) in a mixture of ethyl acetate (400 ml) and MeOH (200 ml), 10% w/w Pd/C (0.900 g) was added, and the mixture was hydrogenated in a Parr apparatus at 30 psi for 2 hours. The catalyst was filtered off, and the filtrate was evaporated to dryness affording tert-butyl 2-(5-amino-1,3-dioxoisoindolin-2-yl)acetate (14 g, 50.7 mmol, 99% yield, MS/ESI+ 276.9 [MH]+). This product was used in the following step without any further purification.

Provenance & Evidence