Potassium Carbonate → HCID 86681699, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 2-(5-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (501 mg, 1.414 mmol) in dry DMF (15 ml) maintained under nitrogen atmosphere, K2CO3 (391 mg, 2.83 mmol) and 4-(2-chloroethyl)morpholine hydrochloride (526 mg, 2.83 mmol) were added, and the mixture was stirred at 60° C. for 3 hours. The solid was filtered off, the solvent was evaporated and the resulting crude was purified by filtration on a silica gel cartridge (DCM/MeOH 9/1), obtaining tert-butyl 2-(5-(N-(2-morpholinoethyl)methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (570 mg, 1.22 mmol, 86% yield, MS/ESI+ 468.2 [MH]+).

Provenance & Evidence