Trifluoroacetic acid → HCID 86681700, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-(5-(N-(2-morpholinoethyl)methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (570 mg, 1.219 mmol) in DCM (15 ml), trifluoroacetic acid (939 μl, 12.19 mmol) was added, and the mixture was reacted for 1 hour at room temperature. The solvent was evaporated and crude 2-(5-(N-(2-morpholinoethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetic acid 2,2,2-trifluoroacetic acid salt was obtained (408 mg, 0.776 mmol, 64% yield).MS/ESI+ 411.8 [MH]+) and used without purification.

Provenance & Evidence