Potassium Carbonate → HCID 86681702, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl 2-(5-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (prepared in an analogous manner as previously described in Example 34, Scheme 34, Steps 1, 2, 3) (400 mg, 1.129 mmol) in acetonitrile (10 ml), potassium carbonate (312 mg, 2.257 mmol), and 1-(2-chloroethyl)piperidine hydrochloride (249 mg, 1.354 mmol) were added. The reaction was heated at 90° C. under microwave irradiation for 2 hours. The solid inorganic salts were filtered off and the filtrate was evaporated to dryness. The resulting crude was crystallized from EtOH affording tert-butyl 2-(1,3-dioxo-5-(N-(2-(piperidin-1-yl)ethyl)methylsulfonamido)isoindolin-2-yl)acetate (450 mg, 0.967 mmol, 86% yield, MS/ESI+ 465.9 [MH]+).

Provenance & Evidence