Hydrochloric Acid → HCID 86681703, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl 2-(1,3-dioxo-5-(N-(2-(piperidin-1-yl)ethyl)methylsulfonamido)isoindolin-2-yl)acetate (450 mg, 0.967 mmol) in dioxane (7 ml), 4 M HCl in dioxane (2.5 ml, 10.00 mmol) was added. The reaction was heated at 100° C. under microwave irradiation for 4 hours. The volatiles were removed under vacuum and the resulting solid was triturated with Et2O and recovered by filtration affording 2-(1,3-dioxo-5-(N-(2-(piperidin-1-yl)ethyl)methylsulfonamido)isoindolin-2-yl)acetic acid hydrochloride (407 mg, 0.913 mmol, 94% yield, MS/ESI+ 409.8 [MH]+).

Provenance & Evidence