Hydrochloric Acid → HCID 86681707, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl 2-(1,3-dioxo-5-(N-(thiophen-2-ylmethyl)methylsulfonamido)isoindolin-2-yl)acetate (580 mg, 1.287 mmol) in dioxane (15 ml), aqueous 12M HCl (1 ml, 12.00 mmol) was added drop wise. The resulting mixture was stirred at 50° C. for 4 hours. The volatiles were removed under vacuum and the crude 2-(1,3-dioxo-5-(N-(thiophen-2-ylmethyl)methylsulfonamido) isoindolin-2-yl)acetic acid (490 mg, 1.242 mmol, 97% yield, MS/ESI+ 395.0 [MH]+). was used without further purification.

Provenance & Evidence