Potassium Iodide → HCID 86681709, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 2-(5-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (600 mg, 1.693 mmol) (prepared in an analogous manner as previously described in Example 34, Scheme 34, Steps 1, 2, 3) in acetone (20 ml), 2-chloro-N,N-dimethylethanamine hydrochloride (366 mg, 2.54 mmol), potassium carbonate (468 mg, 3.39 mmol) and potassium iodide (281 mg, 1.693 mmol) were added. The resulting mixture was stirred at 50° C. for 48 hours. The insoluble inorganic salts were filtered off, and the filtrate was evaporated. The crude was purified by was crystallization from EtOH affording tert-butyl 2-(5-(N-(2-(dimethylamino)ethyl)methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (300 mg, 0.705 mmol, 41.6% yield, MS/ESI+ 426.0 [MH]+).

Provenance & Evidence