Carbon tetrabromide → HCID 86681722, compound

Participants

Reaction Steps

To a solution of benzyl 2-(5-(N-(2-hydroxyethyl)methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (0.690 g, 1.595 mmol) in DCM (18 ml), CBr4 (0.688 g, 2.075 mmol) was added stirring at room temperature. After few minutes triphenylphosphine (0.544 g, 2.075 mmol) was added, and the mixture was stirred at room temperature for 2 hours. The solvent was evaporated under vacuum and the crude was purified by flash chromatography on silica gel column (petroleum ether:ethyl acetate=60:40) affording benzyl 2-(5-(N-(2-bromoethyl)methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (0.759 g, 1.532 mmol, 96% yield, MS/ESI+ 494.8-496.7 [MH]+).

Provenance & Evidence