HCID 86681725, compound → HCID 86681724, compound

Participants

Reaction Steps

A mixture of benzyl 2-(5-(N-(2-(tert-butoxycarbonyl(2-methoxyethyl)-amino)ethyl)methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate (0.166 g, 0.282 mmol) and 10% w/w Pd/C (a catalytic amount) in MeOH was hydrogenated in a Parr apparatus at 30 psi for 3 hours. The catalyst was filtered off and the filtrate was evaporated to dryness affording 2-(5-(N-(2-(tert-butoxycarbonyl(2-methoxyethyl)amino)ethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetic acid (0.138 g, 0.276 mmol, 98% yield, MS/ESI+ 522.0 [MNa]+).

Provenance & Evidence