Potassium Carbonate → HCID 86681733, compound

Participants

Reaction Steps

To a solution of methyl 2-(4-(methylsulfonamido)-1H-indol-1-yl)acetate (1.0 g, 3.54 mmol) (prepared in an analogous manner as described Example 15, Scheme 15, Steps 1, 2, 3) in CH3CN (30 ml), K2CO3 (0.734 g, 5.31 mmol) and 4-(2-chloroethyl)-morpholine hydrochloride (0.989 g, 5.31 mmol) were added, and the resulting mixture heated to reflux for 3 hours. The insoluble inorganic salts were filtered off and the filtrate was evaporated to dryness affording methyl 2-(4-(N-(2-morpholinoethyl)-methylsulfonamido)-1H-indol-1-yl)acetate (1.08 g, 2.73 mmol, 77% yield, MS/ESI+ 395.9 [MH]+) which was used without any additional purification.

Provenance & Evidence