Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-Bromo-6-chloropyrimidin-4-amine | HCID 45789713 | — |
| Reactant | HCID 131736950 | HCID 131736950 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 89442737 | HCID 89442737 | — |
Reaction Steps
The reaction mixture of 5-bromo-6-chloro-pyrimidin-4-ylamine (215.00 mg; 1.03 mmol; 1.0 eq.), 4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl]-piperidine tetrahydrochloride (503.6 mg; 1.03 mmol; 1 eq.), and Cs2CO3 (1344.27 mg; 4.13 mmol; 4 eq.) in DMSO (1.5 ml) was stirred at 120° C. overnight. After cooling, the reaction mixture was poured into water. The precipitate was collected by filtration to yield the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09434714B2 |
|---|
| Source dataset | uspto-grants-2016_09 |
|---|
| ORD ID | ord-534531dbb30244ef8bfe6fd13c3762cf |
|---|
| Source note | uspto-grants-2016_09 |
|---|
