Cesium carbonate → HCID 118290299, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of 6-{4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-bromo-pyrimidin-4-ylamine (90.00 mg; 0.17 mmol; 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazole-1-carboxylic acid tert-butyl ester (61.75 mg; 0.21 mmol; and Cs2CO3 (114.00 mg; 0.35 mmol; in dioxane (5 ml) and water (0.5 ml) was purged with argon, and then added Pd (0) (t-Bu3)2 (6.26 mg; 0.01 mmol; 0.07 eq.). The resulting mixture was stirred at 50° C. overnight. The curde was purified by prep HPLC to afford the title compound.

Provenance & Evidence