3-Pyridinylboronic acid → HCID 118290348, compound

HRID 57136Notes

Reaction equation

HRID 57136 reaction equation
[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([CH3:19])[CH:13]=3)[N:9]=[C:8]2[CH:20]2[CH2:25][CH2:24][N:23]([C:26]3[N:31]=[CH:30][N:29]=[C:28]([NH2:32])[C:27]=3Br)[CH2:22][CH2:21]2)[CH2:4][CH2:3][CH2:2]1.[N:34]1[CH:39]=[CH:38][CH:37]=[C:36](B(O)O)[CH:35]=1>>[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([CH3:19])[CH:13]=3)[N:9]=[C:8]2[CH:20]2[CH2:25][CH2:24][N:23]([C:26]3[N:31]=[CH:30][N:29]=[C:28]([NH2:32])[C:27]=3[C:36]3[CH:35]=[N:34][CH:39]=[CH:38][CH:37]=3)[CH2:22][CH2:21]2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 89442737HCID 89442737, compound

Product 1

HCID 118290348HCID 118290348, compound

Procedure

The title compound was prepared according to the procedure described for the preparation of compound “8” by using 6-{4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-bromo-pyrimidin-4-ylamine and pyridin-3-ylboronic acid as the starting materials. LC-MS (M+H=513, obsd=513).

Workup

  1. customdescribed for the preparation of compound “8”

Sources & evidence

ORD record
ord-3a9714cb30e9488bada9a526ceee0f65
Source dataset
uspto-grants-2016_09
Patent number
US09434714B2

Reaction notes

Loading…