Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | ((3aR,5R,6aR)-5-(((3S*,4S*)-3-Methoxytetrahydro-2H-pyran-4-yl)amino)octahydro-cyclopenta[c]pyrrol-3a-yl)(3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)methanone | HCID 86708896 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ammonia | HCID 222 | 5% |
| Product | (3aR,5R,6aR)-Isobutyl 5-(((3S*,4S*)-3-methoxytetrahydro-2H-pyran-4-yl)amino)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)hexahydro-cyclopenta[c]pyrrole-2(1H)-carboxylate | HCID 89928869 | — |
Reaction Steps
To a solution of Example 1 (0.1 g, 0.213 mmol) and TEA (0.12 mL, 0.854 mmol) in DCM (2.6 mL) at 0° C. was added isobutyl chloroformate (0.086 mL, 0.64 mmol). The mixture was stirred at 0° C. for 30 min and at rt overnight. The reaction was quenched by addition of saturated aqueous NaHCO3 solution, extracted with DCM, dried over Na2SO4. Purification by CombiFlash (eluent: 5% methanol in DCM, then 5% 7N NH3 in methanol in DCM) gave the title compound as a white solid. 1H-NMR (400 MHz, CDCl3): δ 0.93 (d, J=6.3 Hz, 6H), 1.57-1.99 (m, 7H), 2.32 (br. s., 1H), 2.74 (br. s., 1H), 3.08-3.56 (m, 10H), 3.56-4.00 (m, 9H), 4.01-4.11 (m, 1H), 4.57-5.07 (m, 2H), 7.70 (br. s., 1H), 8.72 (br. s., 1H); LC/MS: C28H39F3N4O5: m/z 569.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09024017B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-338c89807cca45ddbb0f1e44ac147e69 |
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| Source note | uspto-grants-2015_05 |
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