HCID 131732817, compound → HCID 89525913, compound

Participants

Reaction Steps

tent-Butyl (3-(4-fluorophenyl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)carbamate (403 mg, 0.706 mmol) was dissolved in HCl (4 M in dioxane, 6 mL) and stirred at room temperature for four hours. The reaction mixture was diluted with ethyl acetate and washed with NaOH (1 N) and brine. The aqueous layer was reextracted with 3:1 chloroform/IPA and the combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo to give 3-(4-fluorophenyl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-amine (359.1 mg, 0.672 mmol, 95%), which was carried onto the next step without further purification. MS ESI calc'd. For C31H23FN4 [M+1]+ 471, found 471.

Provenance & Evidence