HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 571379Generated: October 30, 2026
Xenon difluoride → 7-fluoro-3-(2-methylpyridin-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-amine
https://huagongshe.com/reaction/571379
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Xenon difluoride | HCID 83674 | — |
| Reactant | 3-(2-methylpyridin-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-amine | HCID 89525818 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-fluoro-3-(2-methylpyridin-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-amine | HCID 89525946 | — |
Reaction Steps
A 200 mL round bottom flask was charged with 3-(2-methylpyridin-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-amine (0.76 g, 1.625 mmol) and the flask was put under an atmosphere of argon. The reaction was charged with 10 mL THF and the slurry was cooled to 0° C. in an ice bath. Xenon Difluoride (0.056 ml, 1.418 mmol) was added with vigorous stirring in several portions. Then stirring was continued with warming to ambient temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09023865B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-1b1804e2a21e4750a85f6015b554dbed |
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| Source note | uspto-grants-2015_05 |
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