Trifluoroacetic acid → HCID 178523012, compound

Participants

Reaction Steps

A mixture of 1-(3-cyclopropyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(4-fluorobenzyl)urea (70 mg, 0.123 mmol), TFA (1900 24.66 mmol), and triethylsilane (19.70 μl, 0.123 mmol) was stirred at room temperature. The reaction was concentrated, taken up in DMSO (2 mL) and purified by preparative HPLC (Reverse phase C-18, Waters SunFire PrepODB, 150×19 mm, 5u, eluting with 10-95% Acetonitrile/Water+0.1% TFA (20 mL/min) over 10 min.) to give 1-(3-cyclopropyl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(4-fluorobenzyl)urea (23 mg, 0.052 mmol, 42.5% yield) as an off-white solid. MS ESI calc'd. for C17H16FN5O [M+1]+ 326, found 326.

Provenance & Evidence