HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-[(4S)-7-fluoro-3,4-dihydro-2H-chromen-4-yl]-3-[3-(2-methylpyridin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-1-(7-fluorochroman-4-yl)-3-(3-(2-methylpyridin-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)urea | HCID 89525880 | — |
| Product | 1-[(4S)-7-fluoro-3,4-dihydro-2H-chromen-4-yl]-3-[3-(2-methylpyridin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]urea | HCID 89525921 | — |
Reaction Steps
In a manner similar to that described in Scheme 6 and Example 30, (S)-1-(7-fluorochroman-4-yl)-3-(3-(2-methylpyridin-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)urea was deprotected with TFA to afford 1-[(4S)-7-fluoro-3,4-dihydro-2H-chromen-4-yl]-3-[3-(2-methylpyridin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]urea. MS ESI calc'd. for C22H19FN6O2[M+1]+ 419, found 419.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09023865B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-f2d23c61fba64aff852557bd1fa649e7 |
| Source note | uspto-grants-2015_05 |