Trifluoroacetic acid → HCID 178462161, compound

Participants

Reaction Steps

(R)-1-(3-(cyanomethyl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea (20 mg, 0.036 mmol) was dissolved in TFA (0.274 ml, 3.55 mmol) and stirred for 30 m at rt. The solvents were removed in vacuo and the residue purified by reverse-phase HPLC to provide pure (R)-1-(3-(cyanomethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea (9 mg, 0.021 mmol, 58.3% yield). MS ESI Calc'd for C17H16N6O [M+H]+ 321, found 321.

Provenance & Evidence