3-Pyridinylboronic acid → HCID 118290329, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described for the preparation of compound “8” by using 6-{4-[1-(2-azetidin-1-yl-ethyl)-4-(2-isopropyl-pyridin-4-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-bromo-pyrimidin-4-ylamine and 3-pyridinylboronic acid as the starting materials. LC-MS (M+H=524, obsd=524). 1H NMR (400 MHz, DMSO-d6) δ 8.59-8.50 (m, 2H), 8.38 (dd, J=5.1, 0.8 Hz, 1H), 8.11 (s, 1H), 7.80-7.72 (m, 2H), 7.53-7.47 (m, 2H), 7.43 (dd, J=5.1, 1.6 Hz, 1H), 5.92 (s, 2H), 3.85 (t, J=6.1 Hz, 2H), 3.40-3.27 (m, 5H), 3.63 (d, J=3.1 Hz, 1H), 3.12 (s, 5H), 3.01 (p, J=6.9 Hz, 1H), 2.85 (dt, J=10.1, 5.0 Hz, 1H), 2.77-2.63 (m, 4H), 2.01-1.87 (m, 2H), 1.65-1.52 (m, 4H), 1.25 (d, J=6.9 Hz, 6H).

Provenance & Evidence