HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → US9611269, Example 26
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (RS)-2-Amino-1,1,1-trifluoropropane hydrochloride | HCID 18364314 | — |
| Reactant | 4-{3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-azetidin-1-yl}benzoic acid | HCID 71143612 | — |
| Product | US9611269, Example 26 | HCID 71143548 | — |
Reaction Steps
This compound was prepared as TFA salt by using procedures analogous to those described for the synthesis of Example 19, Step 3 started from 4-{3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}benzoic acid and 1-methyl-2,2,2-trifluoroethylamine hydrochloride (SynQuest Labs: Cat. #93130-7-08). LCMS (M+H)+: m/z=495.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09023840B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-985a1ae25407424d9aba5ed88058ae79 |
| Source note | uspto-grants-2015_05 |