Carbon Dioxide → HCID 67957414, compound

Participants

Reaction Steps

A solution of n-butyl lithium (n-BuLi) (2.5M, 47.2 mL) in hexane was added into 500 mL two neck flask which contained 10.0 g of the product of Step 4 in diethyl ether (200 mL). The mixture was refluxed for five hours, cooled to room temperature, and poured rapidly onto crushed dry-ice. When the temperature of reaction mixture reached room temperature, ethyl acetate (150 mL) was added and the resulting mixture was acidified by concentrated hydrochloric acid. The organic layer was recovered and dried over sodium sulfate. After removing the solvent, 9.4 g of 5-hydroxy-2-methoxy-9-phenyl-7H-benzo[c]fluorene-7-carboxylic acid was obtained as a white solid. This step was repeated to produce additional product for the next step.

Provenance & Evidence