HCID 89979039, compound → HCID 58383065, compound

Participants

Reaction Steps

Bdb was synthesized according to FIG. 15. Briefly, 1-iodo-5-methylanisole (100 mg, 0.4 mmol) was added in to a mixture of 10% Pd on carbon (100 mg) and zinc powder (100 mg, 1.5 mmol) suspended in 5.2 mL of acetone/water (1:1), and the mixture was stirred at room temperature overnight. The solution was extracted with diethyl ether and the ether layer was collected and dried over anhydrous Na2SO4. The ether was removed under reduced pressure and the residue was applied to a flash column chromatography to afford 2,2′-dimethoxy-4,4′-dimethyl biphenyl as a yellow solid (42 mg, 46%). The conversion of 2,2′-dimethoxy-4,4′-dimethyl biphenyl to 4,4′-bis-bromomethyl-2,2′-dimethoxy-biphenyl was accomplished by following a previously reported procedure and resulted in a 31% yield.

Provenance & Evidence