Cesium carbonate → HCID 68285057, compound

Participants

Reaction Steps

To a solution of 4-(2,6-diethyl-4-methylphenyl)-6-hydroxy-5-benzyloxy-2-methyl-3(2H)-pyridazinone (500 mg, 2.35 mmol) in acetone (10 ml) was added iodopropane (443 mg, 2.59 mmol) and cesium carbonate (920 mg, 2.59 mmol), and stirred under reflux for 2.5 hours. The reaction mixture was filtered, and then the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to give 643 mg of Compound (I-8-1) (yield: 70%).

Provenance & Evidence