Hydrochloric Acid → HCID 68284673, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(2,6-diethyl-4-methylphenyl)-6-hydroxymethyl-5-(4-methylphenylsulfonyl)-2-methyl-3(2H)-pyridazinone (2.58 g, 5.85 mmol) in 1,3-dimethylimidazolidinone (30 ml) was added 2N aqueous sodium hydroxide solution (15 ml), and stirred at 70° C. for 12 hours. After cooling to room temperature, 2N hydrochloric acid (25 ml) was added, and extracted with ethyl acetate 2 times. The combined organic layer was washed with water 2 times, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1 to 1:2) to give 842 mg of Compound (I-24-1) (yield: 47%) as solid.

Provenance & Evidence