Hydrochloric Acid → HCID 86699518, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(2,6-diethyl-4-methylphenyl)-6-methoxymethoxymethyl-5-benzyloxy-2-methyl-3(2H)-pyridazinone (2.3 g, 4.91 mmol) in methanol (15 ml) was added concentrated hydrochloric acid (2 ml) and water (1 ml), and stirred at 65° C. for 75 minutes. After cooling to room temperature, the mixture was neutralized with 2N aqueous sodium hydroxide solution, and extracted with ethyl acetate 2 times. The combined organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1) to give 1.64 g of Compound (I-29) (yield: 85%) as solid.

Provenance & Evidence