Sodium Cyanide → HCID 68284963, compound

Participants

Reaction Steps

To a solution of 4-(2,6-diethyl-4-methylphenyl)-6-bromomethyl-5-benzyloxy-2-methyl-3(2H)-pyridazinone (675 mg, 1.48 mmol) in DMSO (4 ml) was added sodium cyanide (80 mg, 1.63 mmol), and stirred at room temperature for 30 minutes. The reaction solution was diluted with water, and extracted with ethyl acetate 2 times. The combined organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to give 405 mg of Compound (I-30) (yield: 66%) as solid.

Provenance & Evidence