Dimethylformamide → HCID 68284326, compound

Participants

Reaction Steps

A solution of (4-(2,6-diethyl-4-methylphenyl)-5-benzyloxy-2-methyl-3(2H)-pyridazinone-6-yl)oxyacetic acid (530 mg, 1.53 mmol), thionyl chloride (290 mg, 2.43 mmol) and DMF (10 mg) in toluene (15 ml) was stirred at 50° C. for 45 minutes. The reaction solution was cooled to room temperature, and then concentrated under reduced pressure. The residue was dissolved in THF (5 ml), and aqueous ammonia (2 ml) was slowly added under ice-cooling. After the reaction solution was stirred at room temperature for 30 minutes, the reaction solution was diluted with water, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and concentrated under reduced pressure to give 500 mg of Compound (I-35-1) (yield: 94%).

Provenance & Evidence