4-Methyloxybenzyl chloride → HCID 86699524, compound

HRID 571613Notes

Reaction equation

[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12]1[C:13](=[O:35])[N:14]([CH3:34])[N:15]=[C:16]([S:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])(=[O:21])=[O:20])[C:17]=1[OH:18])[CH3:2].[CH3:36][O:37][C:38]1[CH:45]=[CH:44][C:41]([CH2:42]Cl)=[CH:40][CH:39]=1>>[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12]1[C:13](=[O:35])[N:14]([CH3:34])[N:15]=[C:16]([S:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])(=[O:21])=[O:20])[C:17]=1[O:18][CH2:42][C:41]1[CH:44]=[CH:45][C:38]([O:37][CH3:36])=[CH:39][CH:40]=1)[CH3:2]

Participants

Reactant 2

HCID 699934-Methyloxybenzyl chloride

HCID 68285059HCID 68285059, compound

Product 1

HCID 86699524HCID 86699524, compoundYield 57%

Procedure

The procedure was performed by the method similar to Production Example 21 using 4-(2,6-diethyl-4-methylphenyl)-6-dodecylsulfonyl-5-hydroxy-2-methyl-3(2H)-pyridazinone and 4-methoxybenzyl chloride as a starting material to give 4-(2,6-diethyl-4-methylphenyl)-6-dodecylsulfonyl-5-(4-methoxybenzyl)oxy-2-methyl-3(2H)-pyridazinone (yield: 57%).

Sources & evidence

ORD record: ord-b20d2fb2994048a680bf7b6d832676e7
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09029295B2

Reaction notes

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