HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-Bromoazepan-4-one hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Azepan-4-one hydrochloride | HCID 22021728 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Bromoazepan-4-one hydrobromide | HCID 22620766 | — |
Reaction Steps
32.2 mL (0.37 mol) Hydrobromic acid (62%) in 50 mL acetic acid were added dropwise to 50.0 g (0.33 mol) hexahydro-4H-azepin-4-one hydrochloride in 0.6 L acetic acid. 17 mL (0.34 mol) bromine in 50 mL acetic acid were added dropwise and the reaction was stirred at room temperature (RT). Then reaction was concentrated and the residue was crystallized with acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029360B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-7c9d6b9f2a0f4da2bebd8c8de1c8c1e3 |
| Source note | uspto-grants-2015_05 |