反应详情

A solution of compound 674-B (2.68 g, 10.9 mmol) in ethanol (30 mL) was treated with 3N aqueous sodium hydroxide (5.4 mL, 16.2 mmol) and refluxed for 2 h. The solution was cooled, and the solvent was evaporated in vacuo. The residue was dissolved in water and washed with dichloromethane. The aqueous phase was acidified with concentrated hydrochloric acid, and the product was extracted into ethyl acetate, washed with brine, dried over Na2SO4, filtered and the solvent was evaporated in vacuo, to afford 1.9 g of compound 674-C as a colorless solid. 1H-NMR (DMSO-d6): δ 0.58-1.37 (m, 4H), 2.44-2.47 (m, 1H), 7.13-7.61 (m, 2H), 7.98 (dd, 2H), 13.33 (br s, 1H).

1. temperaturerefluxed for 2 h
2. temperatureThe solution was cooled
3. customthe solvent was evaporated in vacuo
4. dissolutionThe residue was dissolved in water
5. washwashed with dichloromethane
6. extractionthe product was extracted into ethyl acetate
7. washwashed with brine
8. dry with materialdried over Na2SO4
9. filtrationfiltered
10. customthe solvent was evaporated in vacuo