Dichloromethane → HCID 66722397, compound

Participants

Reaction Steps

Under a nitrogen atmosphere 1.7 g (12.3 mmol) 1-chloroethyl chloroformiate was added to 2.0 g (8.2 mmol) 6-benzyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine (CAS Registry Number: 1159094-24-2) in 20 mL DCM at 0° C. The reaction mixture was stirred at RT for 2 h. The reaction mixture was concentrated and 20 mL anhydrous methanol was added. The reaction mixture was stirred under reflux for 1 h and concentrated. The resulting crude product was washed with DCM, the solid was filtered and dried. Yield: 0.35 g (58% of theory). ESI-MS: m/z=199 (M+H)+; Rt(HPLC): 0.52 min (Method J).

Provenance & Evidence