6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 71748043, compound

HRID 571635Notes

Reaction equation

HRID 571635 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][O:15][C:16]1[CH:17]=[CH:18][C:19]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21][C:20]=2[N:26]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:23]3[CH2:24][CH2:25][C:19]4[CH:18]=[CH:17][C:16]([O:15][CH3:14])=[N:26][C:20]=4[CH2:21][CH2:22]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 58006380HCID 58006380, compound

Product 1

HCID 71748043HCID 71748043, compound

Procedure

The title compound was prepared in accordance with the general method of example 2 from 6-bromo-pyrazolo[1,5-A]pyrimidine-2-carboxylic acid and 2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine. Yield: 0.05 g (60% of theory). ESI-MS: m/z=402 (M+H)+; Rt(HPLC): 1.12 min. (Method J).

Sources & evidence

ORD record
ord-f3da0ddfcad54cb289985252273b0f10
Source dataset
uspto-grants-2015_05
Patent number
US09029360B2

Reaction notes

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