6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → (6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(4,5,7,8-tetrahydro-thieno[2,3-d]azepin-6-yl)-methanone

HRID 571636Notes

Reaction equation

HRID 571636 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[S:14]1[C:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23][C:17]=2[CH:16]=[CH:15]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:21]3[CH2:22][CH2:23][C:17]4[CH:16]=[CH:15][S:14][C:18]=4[CH2:19][CH2:20]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 115137774H,5H,6H,7H,8H-thieno[2,3-d]azepine

Product 1

HCID 71748044(6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(4,5,7,8-tetrahydro-thieno[2,3-d]azepin-6-yl)-methanone

Procedure

The title compound was prepared in accordance with the general method of example 1 from 6-bromo-pyrazolo[1,5-A]pyrimidine-2-carboxylic acid and 5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine. Yield: 56 mg (72% of theory). ESI-MS: m/z=377 (M+H)+; Rt(HPLC): 1.41 min (Method B).

Sources & evidence

ORD record
ord-7067fc960ba4453ca3eab2213a0594fc
Source dataset
uspto-grants-2015_05
Patent number
US09029360B2

Reaction notes

Loading…