6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 71739469, compound

HRID 571637Notes

Reaction equation

HRID 571637 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.Br.[CH2:15]([C:17]1[S:18][C:19]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21][C:20]=2[N:26]=1)[CH3:16]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:23]3[CH2:24][CH2:25][C:19]4[S:18][C:17]([CH2:15][CH3:16])=[N:26][C:20]=4[CH2:21][CH2:22]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 86697863HCID 86697863, compound

Product 1

HCID 71739469HCID 71739469, compound

Procedure

The title compound was prepared in accordance with the general method of example 1 from 6-bromo-pyrazolo[1,5-A]pyrimidine-2-carboxylic acid and 2-ethyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine hydrobromide. The reaction mixture was purified by HPLC chromatography and lyophilized. Yield: 24 mg (29% of theory). ESI-MS: m/z=406 (M+H)+; Rt(HPLC): 1.19 min. (Method J).

Workup

  1. customThe reaction mixture was purified by HPLC chromatography

Sources & evidence

ORD record
ord-fb4c3e046633486a96f76436f9b9537d
Source dataset
uspto-grants-2015_05
Patent number
US09029360B2

Reaction notes

Loading…