6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 178435136, compound

HRID 571639Notes

Reaction equation

HRID 571639 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.Cl.[CH3:15][C:16]1[S:17][C:18]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20][C:19]=2[N:25]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:22]3[CH2:23][CH2:24][C:18]4[SH:17]=[C:16]([CH3:15])[NH:25][C:19]=4[CH2:20][CH2:21]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 226207492-methyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine hydrochloride

Product 1

HCID 178435136HCID 178435136, compound

Procedure

The title compound was prepared in accordance with the general method of example 1 from 6-bromo-pyrazolo[1,5-A]pyrimidine-2-carboxylic acid and 2-methyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine hydrochloride. The reaction mixture was purified by HPLC chromatography and lyophilized. Yield: 13 mg (16% of theory). ESI-MS: m/z=392 (M+H)+;

Workup

  1. customThe reaction mixture was purified by HPLC chromatography

Sources & evidence

ORD record
ord-cee2ed4877364a95ab223394c525c39e
Source dataset
uspto-grants-2015_05
Patent number
US09029360B2

Reaction notes

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