6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 71748064, compound

HRID 571643Notes

Reaction equation

HRID 571643 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.Br.[CH:15]([C:18]1[S:19][C:20]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22][C:21]=2[N:27]=1)([CH3:17])[CH3:16]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:24]3[CH2:25][CH2:26][C:20]4[S:19][C:18]([CH:15]([CH3:17])[CH3:16])=[N:27][C:21]=4[CH2:22][CH2:23]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 86697869HCID 86697869, compound

Product 1

HCID 71748064HCID 71748064, compound

Procedure

The title compound was prepared in accordance with the general method of example 1 from 6-bromo-pyrazolo[1,5-A]pyrimidine-2-carboxylic acid and 2-isopropyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine hydrobromide. The reaction mixture was purified by HPLC chromatography and lyophilized. Yield: 15 mg (17% of theory). ESI-MS: m/z=420 (M+H)+; Rt(HPLC): 1.34 min. (Method J).

Workup

  1. customThe reaction mixture was purified by HPLC chromatography

Sources & evidence

ORD record
ord-a40c8804daf44075ba72d3939a6a496a
Source dataset
uspto-grants-2015_05
Patent number
US09029360B2

Reaction notes

Loading…