HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 71748082, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5H,6H,7H,8H,9H-pyrido[2,3-d]azepine | HCID 23122743 | — |
| Reactant | HCID 86697870 | HCID 86697870 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71748082 | HCID 71748082 | — |
Reaction Steps
75.0 mg (0.21 mmol) 6 (6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(4,5,7,8-tetrahydro-1H-imidazo[4,5-d]azepin-6-yl)-methanone, 13.0 μL (0.21 mmol) methyliodide, 35.0 mg (0.25 mmol) potassium carbonate in 1.0 mL DMF were stirred at RT overnight. The reaction mixture was purified by HPLC chromatography and lyophilized. Yield: 12 mg (15% of theory). ESI-MS: m/z=375 (M+H)+; Rt(HPLC): 0.71 min. (Method K).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029360B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-087b92a7fef3476f9715970924d76e33 |
| Source note | uspto-grants-2015_05 |