Methyl iodide → HCID 71748083, compound

Participants

Reaction Steps

30.0 mg (0.076 mmol) 6-(6-bromo-pyrazolo[1,5-a]pyrimidine-2-carbonyl)-3,4,5,6,7,8-hexahydro-thiazolo[4,5-d]azepin-2-one, 6.3 μL (0.099 mmol) methyliodide, 3.7 mg (0.084 mmol) sodium hydride (50%) in 1.0 mL DMF were stirred at RT for 1 h. The reaction mixture was purified by HPLC chromatography and lyophilized. Yield: 5 mg (16% of theory). ESI-MS: m/z=408 (M+H)+; Rt(HPLC): 0.95 min. (Method N).

Provenance & Evidence