HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67066769, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-Phenylglycine | HCID 66025 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67066703 | HCID 67066703 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67066769 | HCID 67066769 | 52% |
Reaction Steps
To a solution of N-phenylglycine (29 mg, 0.2 mmol), HATU (75 mg, 0.2 mmol), Et3N (50 μL, 0.4 mmol) in DMF (3 mL) was added N-benzyl-1-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine (90 mg, 0.2 mmol). After stirring at rt for 4 h, the solution was diluted with EtOAc and washed with water, aq. citric acid and aq. NaHCO3. The organic phase was dried (Na2SO4), filtered and concentrated in vacuo to afford a residue which was purified by column chromatography (silica gel, gradient EtOAc in hexanes) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029359B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-f02862034ca1464c9fa80a5808fae45a |
| Source note | uspto-grants-2015_05 |