HRID571708

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12278262

4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE

C5H3ClN4

HCID21749030

6-Chloro-N-(propan-2-yl)pyrimidin-4-amine

C7H10ClN3

结构：CC(C)(C)OC(=O)N1CCC[C@@H](NC(=O)[C@H](Nc2cc(F)cc(Cl)c2)C2CC2)C1

HCID67066786

1-Piperidinecarboxylic acid, 3-[[(2R)-2-[(3-chloro-5-fluorophenyl)amino]-2-cyclopropylacetyl]amino]-, 1,1-dimethylethyl ester, (3R)-

C21H29ClFN3O3

结构：CC(C)(C)OC(=O)N1CCC[C@@H](NC(=O)CNc2cc(Cl)cc(Cl)c2)C1

HCID67969283

未命名化合物

PRODUCTS

生成物

结构：CC(C)Nc1cc(N2CCC[C@@H](NC(=O)CNc3cc(Cl)cc(Cl)c3)C2)ncn1

HCID67969246

未命名化合物

PROCEDURE

实验过程

The title compound of Example 142 was prepared in similar manner as described in Example 134 except the key intermediate (R)-tert-butyl 3-((R)-2-(3-chloro-5-fluorophenylamino)-2-cyclopropylacetamido)piperidine-1-carboxylate was replaced with (R)-tert-butyl 3-(2-(3,5-dichlorophenylamino)acetamido)piperidine-1-carboxylate and the 4-amino-6-chloropyrimidine-5-carbonitrile was substituted for 6-chloro-N-isopropylpyrimidin-4-amine. 1H NMR (300 MHz, CD3OD) δ 8.08 (s, 1H), 6.63 (t, J=1.89 Hz, 2H), 6.48 (d, J=1.89 Hz, 3H), 5.72 (s, 1H), 3.78-4.05 (m, 5H), 3.42-3.60 (m, 3H), 1.90-2.08 (m, 2H), 1.80 (td, J=3.59, 8.97 Hz, 3H), 1.65 (td, J=3.21, 8.03 Hz, 2H), 1.13-1.39 (m, 13H). EIMS (m/z): calcd. for C20H26O2N6O (M+1H) 437. found 437.