HRID571711

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID238012

4-Amino-6-chloropyrimidine

C4H4ClN3

HCID12278262

4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE

C5H3ClN4

结构：CC(C)(C)OC(=O)N1CCC[C@@H](NC(=O)[C@H](Nc2cc(F)cc(Cl)c2)C2CC2)C1

HCID67066786

1-Piperidinecarboxylic acid, 3-[[(2R)-2-[(3-chloro-5-fluorophenyl)amino]-2-cyclopropylacetyl]amino]-, 1,1-dimethylethyl ester, (3R)-

C21H29ClFN3O3

结构：CC(C)(C)OC(=O)N1CCC[C@@H](NC(=O)CNc2cc(Cl)cc(Cl)c2)C1

HCID67969283

未命名化合物

PRODUCTS

生成物

结构：Nc1cc(N2CCC[C@@H](NC(=O)CNc3cc(Cl)cc(Cl)c3)C2)ncn1

HCID67969299

未命名化合物

PROCEDURE

实验过程

The title compound of Example 145 was prepared in similar manner as described in Example 134 except the key intermediate (R)-tert-butyl 3-((R)-2-(3-chloro-5-fluorophenylamino)-2-cyclopropylacetamido)piperidine-1-carboxylate was replaced with (R)-tert-butyl 3-(2-(3,5-dichlorophenylamino)acetamido)piperidine-1-carboxylate and the 4-amino-6-chloropyrimidine-5-carbonitrile was substituted for 6-chloropyrimidin-4-amine. 1H NMR (400 MHz, DMSO-d6) δ 8.18 (s, 1H), 8.00 (d, J=7.28 Hz, 1H), 7.50 (br. s., 2H), 6.54-6.70 (m, 1H), 6.47 (d, J=1.76 Hz, 3H), 3.98 (br. s., 1H), 3.84 (br. s., 1H), 3.55-3.71 (m, 6H), 3.06 (dd, J=8.91, 12.93 Hz, 2H), 1.76 (br. s., 3H), 1.38-1.60 (m, 3H). EIMS (m/z): calcd. for C17H20Cl2N6O (M+1H) 395. found 395.