HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-chlorobenzoyl chloride → (RS)-2-(4-Amino-2-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-chlorobenzoyl chloride | HCID 15592207 | — |
| Reactant | Tert-butyl 2-(4-amino-3-fluorophenyl)morpholine-4-carboxylate | HCID 68325450 | — |
| Product | (RS)-2-(4-Amino-2-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester | HCID 68356525 | — |
Reaction Steps
In analogy to (RS)-2-(4-Amino-3-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (Example 1, steps a-g) using 4-bromo-2-chlorobenzoyl chloride (CAS 21900-55-0) instead of 4-bromo-3-fluorobenzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029370B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-107d212c33244558a8da05d6ef47cad7 |
| Source note | uspto-grants-2015_05 |